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KMID : 1139220190150040512
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Journal of Exercise Rehabilitation
2019 Volume.15 No. 4 p.512 ~ p.517
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Effects of a single bout of exercise on mitochondria-mediated apoptotic signaling in rat cardiac and skeletal muscles
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Yoo Su-Zi
No Mi-Hyun
Heo Jun-Won
Chang Eun-Wook
Park Dong-Ho
Kang Ju-Hee
Seo Dae-Yun
Han Jin
Jung Su-Jeen
Hwangbo Kwan
Kwak Hyo-Bum
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Abstract
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This study aimed to determine the effects of a single bout exercise on mitochondria-mediated apoptotic signaling in cardiac and skeletal muscles. Fischer 344 rats (4 months old) were randomly divided into the control or a single bout of exercise group (n= 10 each). The rats performed a single bout of treadmill exercise for 60 min. Mitochondria-mediated apoptotic signaling (e.g., Bax, Bcl-2, mitochondrial permeability transition pore [mPTP] opening, cytochrome c, and cleaved caspase-3) was measured in cardiac (e.g., left ventricle) and skeletal (e.g., soleus and white gastrocnemius) muscles. A single bout of exercise significantly decreased mPTP opening sensitivity in all tissues. However, a single bout of exercise did not show any statistical differences in Bax, Bcl-2, cytochrome c, and cleaved caspase-3 in all tissues measured. A single bout of exercise did not show definite results on characteristics of mitochondria-mediated apoptotic signaling. Therefore, further research is necessary to provide a more mechanistic understanding of the apoptosis pathway.
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KEYWORD
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Apoptosis, Exercise, Mitochondria, Heart, Skeletal muscle
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